TY - JOUR
A1 - Fonseca, Daphne
A1 - Murthy, Sudha
A1 - Tagore, Ravindranath
A1 - Rao, Vishal
A1 - Rao, Chandrashekar
A1 - N. Raju, K
A1 - Nemade, Hemant
A1 - Challa, Sundaram
T1 - BRAF status in the variants of papillary thyroid carcinoma
Y1 - 2018/7/1
JF - International Journal of Head and Neck Pathology
JO - Int J Head Neck Pathol
SP - 41
EP - 47
VL - 1
IS - 2
UR - https://www.ijhnp.org/article.asp?issn=2590-2997;year=2018;volume=1;issue=2;spage=41;epage=47;aulast=Fonseca
DO - 10.4103/JHNP.JHNP_1_19
N2 -
Aim: The aim was to study the BRAF status by immunohistochemistry (IHC) in the variants of papillary carcinoma thyroid and compare it with the clinicopathological parameters.
Materials and Methods: All the thyroid carcinomas diagnosed during the period of January 2015–June 2018 were reviewed and classified according to the WHO 2017 criteria. The demographic and clinicopathological features were noted. Microarrays were prepared on 27 cases, including classic and variants of papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and medullary thyroid carcinoma (MTC). IHC was performed with BRAF V600E by automated staining. The BRAF status was correlated with known prognostic markers.
Results: There were 23 PTC, 3 PDTC, and one MTC. The PTC included seven classic, three solid, two each of microcarcinoma, infiltrative and encapsulated follicular variant, tall-cell variant (TCV), oncocytic and one each of diffuse sclerosing, nodular fasciitis-like stroma, and Warthin-like variants. BRAF positivity was seen in 44.44%, including 11 PTC and one PDTC. The positivity was 85.71% in classic and 31.25% in variants. The age (>45 vs. <45 years), gender (male vs. female), number of lesions (unifocal vs. multifocal), type of tumor (PTC vs. other tumors), subtype of PTC (classic PTC vs. variants), invasion (capsular vs. lymphovascular), and aggressive features (extrathyroidal extension vs. lymph nodal involvement) between BRAF positive and negative tumors were not statistically significant (Fisher's exact test at P < 0.05).
Conclusion: BRAF status did not show correlation with known prognostic variables in classic as well as variants of PTC.
ER -