• Users Online: 27
  • Print this page
  • Email this page


 
 
Table of Contents
LETTER TO EDITOR
Year : 2019  |  Volume : 2  |  Issue : 1  |  Page : 22-23

Cervical neuroblastoma in a 2-month-old child


Department of Pathology, S.R.T.R. Government Medical College, Ambajogai, Maharashtra, India

Date of Submission26-Feb-2020
Date of Decision11-Apr-2020
Date of Acceptance06-Jul-2020
Date of Web Publication28-Oct-2020

Correspondence Address:
Sunil Yogiraj Swami
Bhagwanbaba Chowk, Gitta - Road, Shepwadi, Beed, Ambajogai, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JHNP.JHNP_3_20

Rights and Permissions

How to cite this article:
Chate MA, Swami SY. Cervical neuroblastoma in a 2-month-old child. Int J Head Neck Pathol 2019;2:22-3

How to cite this URL:
Chate MA, Swami SY. Cervical neuroblastoma in a 2-month-old child. Int J Head Neck Pathol [serial online] 2019 [cited 2020 Nov 24];2:22-3. Available from: https://www.ijhnp.org/text.asp?2019/2/1/22/299469



Sir,

Neuroblastoma is one of the common childhood malignancies. It originates from the neural crest of adrenal medulla or sympathetic ganglia.[1] The 3rd most common extracranial solid neurogenic tumor of infancy and childhood is neuroblastoma along the peripheral sympathetic nervous system. Neuroblastoma may be sporadic or nonfamilial in origin, the exact etiology of which is not well understood. However, recent studies have improved the understanding of genetic susceptibility to neuroblastoma.[2] Nearly 70% of neuroblastoma that are discovered in the head-and-neck region are metastatic lesions.[3]

A 2-month-old female baby was admitted in the surgery department with the complaints of swelling over the left side of the neck [Figure 1] of size 3 cm × 3 cm, which was well defined, immobile, nontender, nonpulsatile with smooth surface, and firm in consistency. It was progressively increasing in size. Family history was noncontributory.
Figure 1: Left neck swelling: 3 cm × 3 cm, well defined with smooth surface, and firm in consistency

Click here to view


Computed tomography scan demonstrated a neoplastic, solid, minimally enhancing, soft-tissue mass in the left neck involving the carotid space extending superiorly up to the left parapharyngeal space and inferiorly up to the thyroid level.

Fine-needle aspiration cytology [Figure 2] revealed cellular smears with monomorphic population of cells having salt and pepper chromatin nuclei, features suggestive of neuroendocrine tumor (NET). Biopsy revealed [Figure 3] multiple tissue bits aggregating 5 cm × 3 cm. Histopathology [Figure 4] revealed lobular arrangement of tumor cells with Holmer–Wright pseudo rosettes admixed with necrosis, suggesting a poorly differentiated neuroblastoma, which was confirmed on immunohistochemistry (IHC) [Figure 5] as tumor cells were positive for CD56, neuron-specific enolase, and chromogranin and negative for leukocyte common antigen, Tdt, desmin, and S100 protein.
Figure 2: Fine-needle aspiration cytology: Cellular smears with monomorphic population of cells with salt and pepper chromatin nuclei (Pap: ×40)

Click here to view
Figure 3: Gross: Multiple tissue bits aggregating 5 cm × 3 cm

Click here to view
Figure 4: (a-c) Lobular arrangement of tumor cells with Holmer–Wright pseudo rosettes admixed with necrosis

Click here to view
Figure 5: Immunohistochemistry: Positive for CD56, neuron-specific enolase, and chromogranin

Click here to view


Neuroblastoma is detected in 1/7000 live births.[4] Head-and-neck NET s are uncommon. The pathological diagnosis of NETs in head-and-neck area may be difficult just because of the low frequency of these tumors in that location. The diagnosis is based on histological, ultrastructural, and IHC criteria.

IHC study is also useful to distinguish other malignant, small, round cell neoplasms that may be considered in the differential diagnosis, as sinonasal undifferentiated carcinoma, basaloid squamous carcinoma, non-Hodgkin lymphoma, and paraganglioma.[5],[6],[7]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Shah S, Champaneria N, Pasle RK. Neuroblastoma in 3 months old infant – A rare case report. IAIM 2016;3:362-5.  Back to cited text no. 1
    
2.
Amit KD, Prashant S, Richa S, Kas K. Head neck neuroblastoma in early childhood: A rare case report. Int J Med Sci 2017;5:5466-9.  Back to cited text no. 2
    
3.
Singh H, Mohan C, Mohindroo NK, Sharma DR. Cervical neuroblastoma. Indian J Otolaryngol Head Neck Surg 2007;59:288-90.  Back to cited text no. 3
    
4.
London WB, Castleberry RP, Matthay KK, Look AT, Seeger RC, Shimada H, et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J Clin Oncol 2005;23:6459-65.  Back to cited text no. 4
    
5.
Berthold F, Simon T. Clinical presentation. In: Cheung, Nai-Kong V, Cohn, Susan L, editors. Neuroblastoma. Springer; 2006. p. 63-85.  Back to cited text no. 5
    
6.
Meacham R, Matrka L, Ozer E, Ozer HG, Wakely P, Shah M. Neuroendocrine carcinoma of the head and neck: A 20-year case series. Ear Nose Throat J 2012;91:E20-4.  Back to cited text no. 6
    
7.
Citak C, Karadeniz C, Dalgic B, Oguz A, Poyraz A, Okur V, et al. Intestinal lymphangiectasia as a first manifestation of neuroblastoma. Pediatr Blood Cancer 2006;46:105-7.  Back to cited text no. 7
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References
Article Figures

 Article Access Statistics
    Viewed78    
    Printed0    
    Emailed0    
    PDF Downloaded8    
    Comments [Add]    

Recommend this journal